Bioactive metabolites are a substance that has a biological activity and should include all microbial compounds obtained either from microbes or from any other living thing. Around 23,000 bioactive metabolites produced from microorganisms, out of which 10,000 (45%) are produced by Actinobacteria alone. Actinomycetes are known to produce an extensive range of bioactive metabolites as well as variety of enzymes with multiple biotechnological applications and important for pharmaceutical, food, agricultural, and environmental applications. Bioactive metabolites are widely used and studied for obtaining antibiotics, antifungals, antivirals, immunosuppressants, compounds with anticancer and antioxidant activity, enzymes, bioinsecticides, biostimulants, biosurfactants and other applications. Bioactive metabolites derived from Actinomycetes are more attractive than bioactive metabolites from other sources because of their high stability and unusual activity specificity. The main applications of Actinomycetes, studies have focused on antimicrobial potential, enzymes production, agricultural uses, bioremediation, and others related to their secondary metabolites production. The review aimed to summarize information about the potentials of Actinomycetes novel bioactive metabolites with their applications in different prospects.
microorganisms, Actinomycetes, Streptomyces, secondary metabolite, antibiotics
Yiglet Mebrat. Ethiopian Biodiversity Institute, Addis Ababa, Ethiopia.
Abdel-Aziz Mohamed, S., Amal, S., Hathout Aziza, A., El-Neleety, Ahmed A., Hamed, Bassem A Sabry, Soher E Aly, Mosaad Attia Abdel-Wahhab. (2019). Molecular identification of actinomycetes with antimicrobial, antioxidant and anticancer properties. Com. Sci., Bom Jesus, 10(2): 218-231. https://doi.org/10.14295/CS.v10i2.2269
Abdelaziz, R., Tartor, Y.H., Barakat, A.B., EL-Didamony, G., Gado, M.M., Berbecea, A. & Radulov, H.I. (2023). Bioactive metabolites of Streptomyces misakiensis display broad-spectrum antimicrobial activity against multidrug-resistant bacteria and fungi. Front. Cell. Infect. Microbiol. 13, 1162721. https://doi.org/10.3389/fcimb.2023.1162721
Abdel-Aziz, S.M., Abo Elsoud, M.M. & Anise, A.A.H. (2017). Microbial biosynthesis: A repertory of vital natural products. Handbook of Food Bioengineering, 25-54. https://doi.org/10.1016/B978-0-12-811372-1.00003-8
Abdelghani, Z., Hourani, N., Zaidan, Z., Dbaibo, G., Mrad, M., & Hage-Sleiman, R. (2021). Therapeutic applications and biological activities of bacterial bioactive extracts. Arch Microbiol. 203(8), 4755-4776. https://doi.org/10.1007/s00203-021-02505-1
Ait Barka, E., Vatsa, P., Sanchez, L., Gaveau-Vaillant, N., Jacquard, C., Klenk, H.-P., Clément, C., Ouhdouch, Y. & Van Wezel, G. P. (2016). Taxonomy, physiology, and natural products of Actinobacteria. Microbiol. Mol. Biol. Rev., 80: 1-43. https://doi.org/10.1128/MMBR.00019-15
Al-Khayri, J.M., Rashmi, R., Toppo, V., Chole, P.B,, Banadka. A,, Sudheer. W,N., Nagella, P., Shehata, W.F., Al-Mssallem, M.Q., Alessa, F.M., Almaghasla, M.I., & Rezk, A.A. (2023). Plant secondary Metabolites: The weapons for biotic stress management. Metabolites, 31, 13(6), 716. https://doi.org/10.3390/metabo13060716
Amaning Danquah, C., Minkah, P.A.B., Osei Duah Junior, I., Amankwah, K.B. & Somuah, S.O. (2022). Antimicrobial compounds from microorganisms. Antibiotics, 11(3), 285. https://doi.org/10.3390/antibiotics11030285
Atuanya, E.I., Dunkwu-Okafor, A. & Udochukwu, U. (2016). Production of Biosurfactants by Actinomycetes isolated from hydrocarbon contaminated soils and Ikpoba River Sediments in Benin-City, Nigeria. Nigerian Journal of Basic and Applied Science, 24(2), 45-52. https://doi.org/10.4314/njbas.v24i2.7
Bérdy, J. (2012). Thoughts and facts about antibiotics: where we are now and where we are heading. J. Antibiot. 65, 385-395. https://doi.org/10.1038/ja.2012.27
Brzezinska, M.S., Jankiewicz, U., Burkowska, A., & Walczak, M. (2014). Chitinolytic microorganisms and their possible application in environmental protection. Curr. Microbiol, 68(1), 71-81. https://doi.org/10.1007/s00284-013-0440-4
Chaturvedi, S. & Gupta, P. (2021). Plant secondary metabolites for preferential targeting among various stressors of metabolic syndrome. Studies in Natural Products Chemistry, 71, 221-261. https://doi.org/10.1016/B978-0-323-91095-8.00012-X
Chen, D., Mubeen, B., Hasnain, A., Rizwan, M., Adrees, M., Naqvi, S.A.H., Iqbal, S., Kamran, M., El-Sabrout, A.M., Elansary, H.O., Mahmoud, E.A., Alaklabi, A., Sathish, M. & Din, G.M.U. (2022). Role of promising secondary Metabolites to confer resistance against environmental stresses in crop plants: Current scenario and future perspectives. Front. Plant Sci. 13, 881032. https://doi.org/10.3389/fpls.2022.881032
Conrado, R., Gomes, T.C., Roque, G.S.C., & De Souza, A.O. (2022). Overview of bioactive fungal secondary Metabolites: Cytotoxic and antimicrobial compounds. Antibiotics (Basel), 11(11), 1604. https://doi.org/10.3390/antibiotics11111604
De Simeis, D. & Serra, S. (2021). Actinomycetes: A never-ending source of bioactive compounds-an overview on antibiotics production. Antibiotics (Basel), 22, 10(5):483. https://doi.org/10.3390/antibiotics10050483
Divekar, P.A., Narayana, S., Divekar, B.A., Kumar, R., Gadratagi, B.G., Ray, A., Singh, A.K., Rani, V., Singh, V., Singh, A.K., Kumar, A., Singh, R.P., Meena, R.S., & Behera, T.K. (2022). Plant secondary Metabolites as defense tools against herbivores for sustainable crop protection. Int J Mol Sci. 28, 23(5), 2690. https://doi.org/10.3390/ijms23052690
Golinska, P., Wypij, M., Agarkar, G., Rathod, D., Dahm, H., & Rai, M. (2015). Endophytic actinobacteria of medicinal plants: diversity and bioactivity. Antonie Van Leeuwenhoek, 108(2), 267-89. https://doi.org/10.1007/s10482-015-0502-7
Gomes Edelvio, de B., Dias, L.R.L., de Cássia, R. & de Miranda, M. (2018). Actinomycetes bioactive compounds: Biological control of fungi and phytopathogenic insect. African Journal of Biotechnology, 17(17), 552-559. https://doi.org/10.5897/AJB2017.16323
Hamed Moaz, M., Abdrabo, M.A.A & Youssif, A.M. (2021). Biosurfactant production by marine Actinomycetes Isolates Streptomyces althioticus RG3 and Streptomyces californicus RG8 as promising sources of antimicrobial and antifouling effects. Microbiol. Biotechnol. Lett, 49(3): 356–366. https://doi.org/10.48022/mbl.2106.06007
Hashem, A.H., Attia, M.S., & Kandil, E.K. (2023). Bioactive compounds and biomedical applications of endophytic fungi: a recent review. Microb Cell Fact 22, 107 (2023). https://doi.org/10.1186/s12934-023-02118-x
Jagannathan, S.V., Manemann, E.M., Rowe, S.E., Callender, M.C., & Soto, W. (2021). Marine actinomycetes, new sources of biotechnological products. Mar Drugs, 25, 19(7):365. https://doi.org/10.3390/md19070365
Janardhan, A., Kumar, A.P., Viswanath, B., Saigopal, D.V., & Narasimha, G. (2014). Production of bioactive compounds by actinomycetes and their antioxidant properties. Biotechnol Res Int. 217030. https://doi.org/10.1155/2014/217030
Kekuda, T.R.P., Shobha, K.S., & Onkarappa, R. (2010). Fascinating diversity and potent biological activities of actinomycetes metabolites. Journal of Pharmacy Research. 3, 250-256.
Lewis, R.A., Devi, J., & Green, K. (2021). Screening and purification of natural products from Actinomycetes that induce a “rounded” morphological phenotype in fission yeast. Nat. Prod. Bioprospect. 11, 431–445. https://doi.org/10.1007/s13659-021-00304-1
Limaye, L., Patil, R., Ranadive, P. & Kamath, G. (2017). Application of potent actinomycete strains for bio-degradation of domestic Agrowaste by composting and treatment of pulp-paper mill effluent. Advances in Microbiology, 7, 94-108. http://dx.doi.org/10.4236/aim.2017.71008
Maithani, D., Sharma, A., Gangola, S., Chaudhary, P. & Bhatt, P. (2022). Insights into applications and strategies for discovery of microbial bioactive metabolites. Microbiological Research, 261, 127053. https://doi.org/10.1016/j.micres.2022.127053
Marinelli, F. & Marcone, G.L. (2011). Microbial Secondary Metabolites. Comprehensive Biotechnology, 3, 285-297. https://doi.org/10.1016/B978-0-08-088504-9.00539-0
Matsumoto, A., & Takahashi, Y. (2017). Endophytic actinomycetes: promising source of novel bioactive compounds. J Antibiot 70, 514–519. https://doi.org/10.1038/ja.2017.20
Meenakshi, S., Hiremath, J., Meenakshi, M.H., & Shivaveerakumar, S. (2024). Actinomycetes: Isolation, Cultivation and its Active Biomolecules. J Pure Appl Microbiol. 18(1), 118-143. https://doi.org/10.22207/JPAM.18.1.48
Najm, B.Y., Khallel, S.H., & Majeed, H.M. (2023). Evaluation of the antimicrobial producing actinomycetes from Regions in Baghdad City. Biochem Mol Biol J., 9, 32.
Nazari Mateus Torres, Bruna Strieder Machado, Giovana Marchezi, Larissa Crestani, Valdecir Ferrari, Luciane Maria Colla, & Jeferson Steffanello Piccin (2022). Use of soil actinomycetes for pharmaceutical, food, agricultural, and environmental purposes. 3 Biotech, 12, 232. https://doi.org/10.1007/s13205-022-03307-y
Ncube, B., Ndhlala, A.R., & Van Staden, J. (2016). Secondary metabolism and the rationale for systems manipulation. In: Jha, S. (eds) Transgenesis and Secondary Metabolism. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-27490-4_23-1
Neha Salaria, Sandeep Sharma, & Sarika Sharma (2017). Actinomycetes: Potential and Applications. IJAPRR, 4(8), 32-43.
Nodwell, J.R. (2017). Antimicrobials: Expressing antibiotic gene clusters. Nat. Microbiol., 2, 17061. https://doi.org/10.1038/nmicrobiol.2017.61
Olano, C., & Rodríguez, M. (2024). Actinomycetes associated with arthropods as a source of new bioactive compounds. Current Issues in Molecular Biology, 46(5), 3822-3838.
Osama, N., Bakeer, W., Raslan, M., Soliman, H.A., Abdelmohsen, U.R., & Sebak, M. (2022). Anti-cancer and antimicrobial potencil of fve soil streptomycetes: a metabolomics-based study. R Soc Open Sci., 9(2), 211509. https://doi.org/10.1098/rsos.211509
Ouchari, L., Boukeskasse, A., Bouizgarne, B., & Ouhdouch, Y. (2019). Antimicrobial potential of actinomycetes isolated from the unexplored hot Merzouga desert and their taxonomic diversity. Biol Open. 8(2), 1-7. https://doi.org/10.1242/bio.035410
Prakash Divya, Neelu Nawani, Mansi Prakash, Manish Bodas, Abul Mandal, Madhukar Khetmalas, & Balasaheb Kapadnis (2013). Actinomycetes: A repertory of green catalysts with a potential revenue resource. BioMed Research International, 1-9. http://dx.doi.org/10.1155/2013/264020
Raihan, T., Rabbee, M.F., Roy, P., Choudhury, S., Baek, K.H. & Azad, A.K. (2021). Microbial Metabolites: The emerging hotspot of antiviral compounds as potential candidates to avert viral pandemic alike COVID-19. Front. Mol. Biosci. 8, 732256. https://doi.org/10.3389/fmolb.2021.732256
Rajivgandhi, G., Gnanamangai, B.M., Prabha, T.H., Poornima, S., Maruthupandy, M., Alharbi, N.S,, & Li, W.J. (2022). Biosynthesized zinc oxide nanoparticles (ZnO NPs) using actinomycetes enhance the antibacterial efcacy against K. Pneumoniae. J. King Saud Univ Sci., 34(1), 101731. https://doi.org/10.1016/j.jksus.2021.101731
Richa, S. (2015). Studies on bioactive compounds from different microorganisms international J.Scie. Engin res., 6, 125-132.
Ryu, D., Hillman, P.F., Akinniyi, G., Nam, S.J. & Yang, I. (2023). Marine mudflat actinomycetes as a novel natural products source. Front. Mar. Sci. 10, 1297446. https://doi.org/10.3389/fmars.2023.1297446
Saadoun, I., Al-Joubori, B. & Al-Khoury, R. (2015). Testing of production of inhibitory bioactive compounds by soil Streptomycetes as preliminary screening programs in UAE for anti-cancer and anti-bacterial drugs. Int. J. Curr. Microbiol. App. Sci., 4, 446-459.
Saloni Jain, Ishita Gupta, Priyanshu Walia & Shalini Swami (2022). Application of Actinobacteria in agriculture, nanotechnology, and bioremediation. IntechOpen, 1-30. http://dx.doi.org/10.5772/intechopen.104385
Salwan, R. & Sharma, V. (2020). Molecular and biotechnological aspects of secondary metabolites in actinobacteria. Microbiological Research, 231, 126374. https://doi.org/10.1016/j.micres.2019.126374
Sanscartier, D., Zeeb, B., Koch, I. & Reinmer, K. (2009). Bioremediation of diesel-contaminated soil by heated and humidified biopile system in cold climates. Cold regions Sci. Technol., 55, 167-173. https://doi.org/10.1016/j.coldregions.2008.07.004
Sathya, A., Vijayabharathi, R., & Gopalakrishnan, S. (2017). Plant growth promoting actinobacteria: A new strategy for enhancing sustainable production and protection of grain legumes. 3 Biotech, 7(2), 102:110. https://doi.org/10.1007/978-981-10-0707-1
Sharma Mukesh, Pinki Dangi & Meenakshi Choudhary (2014). Actinomycetes: Source, identification, and their applications. Int. J. Curr. Microbiol. App. Sci. 3(2): 801-832.
Sharma, V., Malla, M.A. & Kori1, R.K., Yadav, R. & Azam, Z. (2021). Applications of metagenomics for unrevealing the extended horizons of microbiota prevalence from soil to human health. The Open Microbiology Journal, 15, (Suppl-1, M4) 177-187. https://doi.org/10.2174/1874285802115010177
Silva, G.C., Kitano, I.T., Ribeiro, I.A.F. & Lacava, P.T. (2022). The potential use of Actinomycetes as microbial inoculants and Biopesticides in agriculture. Front. Soil Sci. 2, 833181. https://doi.org/10.3389/fsoil.2022.833181
Singh, V., Haque, S., Singh, H., Verma, J., Vibha, K., Singh, R., Jawed, A. & Tripathi, C.K.M. (2016). Isolation, screening, and identification of novel isolates of Actinomycetes from India for antimicrobial applications. Front. Microbiol. 7, 1921, 1-9. https://doi.org/10.3389/fmicb.2016.01921
Subramani, R. & Aalbersberg, W. (2012). Marine actinomycetes: An ongoing source of novel bioactive metabolites. Microbiological Research, 167(10). 571-580. https://doi.org/10.1016/j.micres.2012.06.005
Sutaria Devanshi, Kamlesh R. Shah, Sudipti Arora & Sonika Saxena (2021). Actinomycetes as an environmental Scrubber. Licensee IntechOpen. 1-19. http://dx.doi.org/10.5772/intechopen.99187
Thomashow, L.S., Bonsall, R.F., & Weller, D.M. (2008). Detection of antibiotics produced by soil and rhizosphere microbes in situ. In Karlovsky, P., (ed). Secondary Metabolites in Soil Ecology (pp. 23–36). Springer.
Vaishnav, P. & Demain, A.L. (2010). Unexpected applications of secondary metabolites. Biotechnol.Adv. 29, 223-229.
Vijayakumar, R., & Raja, S.S.S. (Eds.). (2018). Secondary Metabolites – Sources and applications. InTech. https://doi.org/10.5772/intechopen.71955
Cite this article:
Mebrat, Y. (2024). Production of secondary metabolites by Actinomycetes and their biological applications: A review. International Journal of Science, Technology, Engineering and Mathematics, 4(3), 154-172. https://doi.org/10.53378/ijstem.353099
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