The intense global business competition has triggered companies to establish effective strategies to realized long-term competitive advantages. The purpose of the study was to first determine the moderating effect of ICT capability on the relationship between supply chain agility and competitive advantage and, second, determine the relationship between supply chain agility, ICT capability, and competitive advantage among 300 drugstores in Region XI. It made use of quantitative research design, specifically the descriptive-correlational. An adapted and modified research instrument was used in gathering the data. Hierarchical logistic regression was used to analyze the moderating effect of ICT capability on the relationship between supply chain agility and competitive advantage. The findings revealed that the overall levels of supply chain agility, ICT capability, and competitive advantage of drugstores are all high. The interrelationship among variables was found to be significant. Finally, supply chain agility and competitive advantage relationships were not significantly moderated by ICT capability.