Understanding what makes businesses last is vital for building resilient and enduring enterprises, ultimately contributing to the economic strength and stability of the Davao Region. Hence, this study primarily aims to determine the factor that has the most significant influence on Business Longevity of MSMEs in Davao Region. This study employed a descriptive-correlational research design alongside path analysis to comprehensively examine the interrelationships among variables. Data were gathered using survey questionnaires from 300 owners, manager and supervisor of MSME in Davao Region, Philippines using Proportional Stratified Random Sampling. The statistical used in the study are Mean, Pearson R and Path Analysis. Based on the result, the level of Entrepreneurial Competencies and Financial Literacy of the MSME owner, manager and supervisor is High. The level of Innovation and Business Longevity of the MSMEs is also high. Also, using the Pearson-R result revealed that entrepreneurial competencies and financial literacy, financial literacy and innovation, entrepreneurial competencies and innovation has significant relationship. Moreover, it was found out that only entrepreneurial competencies and innovation has the direct effect to business longevity having entrepreneurial competencies as the variable with the most effect. Financial Literacy has an indirect effect to business longevity through innovation. Result also showed that after path analysis, only entrepreneurial competencies and financial literacy was found to have significant relationship. The study was able to establish the path analysis and their relationships are significant.