Negative automatic thoughts are the conscious or subconscious thoughts that occur involuntarily in response to everyday events. These thoughts are irrational, self-defeating, and indicative of negative core beliefs someone has about themself. The study’s goal was to assess how the college students cope with negative automatic thoughts using the techniques of cognitive defusion. Its specific goal was to ascertain whether the pre-and post-test results of the experimental group and the control group differed in a statistically significant way. The results indicated that while there is a significant difference between the means of the two groups' post-test scores, there is no significant difference between any group's means of the pre-test scores. Additionally, the mean scores of the groups that received cognitive defusion techniques and those that did not receive an intervention differed significantly before and after the test. Finally, using cognitive defusion techniques is an effective method in coping with negative automatic thoughts of college students.