COVID-19 pandemic has brought the nation’s capital healthcare system into its critical mass, leaving the front-liners at significant risk while sacrificing their lives to fight against the COVID-19. This study aimed to determine the relationship between the respondent’s profile, health risk, life satisfaction, and death anxiety. This study utilized a quantitative, descriptive-correlational design and a purposive sampling technique that involved 100 front-line healthcare workers from Tayabas, Quezon. All the research instruments used in conducting the study were researcher-made questionnaires, validated by experts, and underwent pilot testing. The research instruments are the personal information sheet, health risk questionnaire, including two factors: the physical and mental health risk with a good reliability score of 0.889, the life satisfaction questionnaire with a good reliability score of 0.852, and the death anxiety questionnaire with an excellent reliability score of 0.918. To find the relationship between variables, Pearson’s correlation coefficient was used. Meanwhile, the relationship between death anxiety and the respondents’ profile was found that all factors are not significant except for the years of employment, which has a significant inverse relationship. The relationship between death anxiety and the health risk of the respondents in terms of physical health risk and death anxiety has a significant relationship; in terms of mental health risk and death anxiety, it also has a significant relationship. The relationship between life satisfaction and death anxiety has a significant inverse relationship. Furthermore, this study suggests providing intervention to prevent death anxiety by improving the front-liners’ physical, mental health, and life satisfaction.