This research aimed to know the effect of strand-course mismatch on college students academic, psychological, and career trajectories. The design presents a non-experimental quantitative study that investigates the impact of strand-course mismatches on college students’ academic, psychological, and career trajectories. Through a survey-based approach, the study seeks to answer specific research questions aligned with the survey questionnaire. The research sample comprises 20 third-year college students from diverse schools, with survey administration facilitated through online platforms like Google Forms, utilizing email, and messenger applications. The study encompasses materials used, procedures followed, questionnaire content, and statistical treatment applied to the collected data. The findings highlight the prevalence of mismatches, their correlation with academic performance and psychological well-being, and various factors contributing to these mismatches. Furthermore, the research supports the significance of improved preparation and targeted guidance during the transition from high school to college to alleviate the occurrence of mismatches. Overall, this research offers valuable insights into the complexity of strand-course mismatches and underscores the importance of tailored support mechanisms to enhance college students’ holistic development and success.