The control of the invasive species golden apple snail, Pomacea canaliculata, plays a crucial role in preventing the continuing destruction of lowland rice production in the Philippines. However, some molluscicides are considered unpractical because of their toxic effect on non-target organisms, hence this study on innovative, plant-based extract to control golden apple snails. Leaves of pipinong gubat, Melothria pendula,were collected, air-dried, pulverized and macerated in ethanol. The extracts were subjected to a water bath at 80 ºC for four hours. Active snails were immersed in solutions of 5mL/L, 10mL/L, and 15mL/L of Melothria pendula leaf extract for 24h and 48h.The snail mortality was determined and LC50 & LC90 values were calculated. Treatment 3 (15mL/L) got the highest mortality rate, 90% and 97% among other concentrations used in 24 hours and 48 hours, respectively. The control group, bayluscide, attained 100% mortality both in 24 hours and 48 hours. Statistical analysis revealed that the LC50 and LC90 values of 48 hours of exposure showed an increased toxicity level against the snails than of 24 hours of exposure. Moreover, there is a significant difference between the effects of different concentrations and days of exposure on the mortality rate of the snail. Results indicated that Melothria pendula extract is a novel, environment- friendly molluscicide to control Pomacea canaliculata.