This descriptive-correlational study aimed to investigate the relationship between food safety knowledge and hygiene practices among street vendors. There were 150 respondents of street vendors in Barangay Tibal-og, Santo Tomas Davao del Norte who were chosen through universal sampling. This study used two adopted questionnaires. Mean, pearson r, and standard deviation were used as statistical tools. The findings of the study showed that food safety knowledge in terms of transmission of food-borne diseases, personal and health hygiene, cross-contamination, and temperature control is much observed. Hygiene practices of street vendors are much evident. The results of this study showed that the food safety knowledge of street vendors has a great influence on hygiene practices. It implies that the knowledge of food safety leads to good hygienic practices, as vendors who understand the importance of food safety are more likely to take measures to ensure their personal and food hygiene is also up to standard. Therefore, it was hoped that this study could influence street vendors to prioritize and adopt good hygiene practices in the hope of achieving several positive outcomes, including increased sales and a positive reputation among customers. By emphasizing the importance of hygiene, the researchers hoped to create awareness among vendors about the impact it can have on their businesses. Also, this study recommends that customers be urged to patronize businesses that place a high priority on cleanliness and safety.