Immunization is a critical public health intervention that has significantly reduced childhood morbidity and mortality rates worldwide. The success of immunization programs relies heavily on the knowledge and attitudes of mothers towards vaccines, as they are the primary decision-makers for their children's healthcare. This study aimed to determine the mother's level of knowledge and attitude toward routine immunization at Kalinga Provincial Hospital. Utilizing a cross-sectional descriptive design, data were collected from 48 mothers through a modified questionnaire. Findings revealed a prevailing low knowledge level, emphasizing significant gaps in understanding vaccination schedules, doses, and preventable diseases. While the majority expressed positive attitudes, a subset retained misconceptions, influenced by cultural, religious, and alternative healing practices. Notably, older mothers exhibited more favorable attitudes, aligning with their potentially stronger influence on vaccination decisions. Research limitations include a small sample size and geographical specificity, impacting generalizability. However, these constraints are acknowledged to provide transparency about the study's scope. Implications suggest the need for tailored educational campaigns, considering sociodemographic factors and collaborating with indigenous communities. Cultural and religious considerations should be incorporated into communication strategies to dispel myths and build trust. The study underscores the importance of healthcare providers' role in addressing concerns and promoting comprehensive vaccine literacy. Future research should explore specific factors contributing to knowledge gaps, guiding targeted interventions.