Zero plastic policy bans the use of unnecessary plastic or single use plastic to promote a greener environment and to reduce harmful, non-biodegradable waste. This study investigates the business profile, plastic use policies, perceived usefulness, and level of awareness as the determinants of willingness to adopt zero plastic policy of the micro, small, and medium sized enterprises (MSMEs) in the central business district of Goa, Camarines Sur. The study used a descriptive research method, where questionnaires were used to gather data from 105 respondents. Results show that majority of the respondents are highly aware of the zero plastic policy and are willing to implement it as one of their business policies. Based on the regression analyses, it appears that existing plastic use policies, perceived usefulness, level of awareness, age, and number of employees have a direct relationship with the business’ willingness to adopt zero plastic policy. The researchers concluded that the aforementioned factors are the determinants of the willingness to adopt zero plastic policy of MSMEs in the central business of Goa, Camarines Sur, Philippines. Using the results of this study as foundation, the researchers recommend transformative activities such as awareness campaigns, capacity building and policy integration, and for a follow-up research covering this study’s limitations.