Head lice, or pediculosis, is a global health problem affecting people of all age groups worldwide. It poses a significant concern for the health of individuals, particularly children, as well as their social interactions with their peers. This study investigated the pediculicidal abilities of coconut milk and macerated atis leaves in three concentrations, namely, 50:50, 75:25, and 25:75. The study used a true experimental design. It was done in triplicate via in vitro experimentation. 3 head lice per ratio and the control group were placed in a plastic container with filter paper treated with the solutions at the bottom. The researchers derived from the average time-to-reach mortality rate that a 25:75 ratio of coconut milk and atis leaves yields the fastest pediculicidal effect. An independent t-test showed a non-significant p-value between Eradequine and the Kwell (a commercial pediculicide). Pearson r results also revealed a positive correlation between Eradequine and the death of the lice.