Mnemonic devices aid in retaining scientific knowledge by simplifying complex concepts, stimulating curiosity, and engaging students through question-based learning, thereby enhancing their overall learning experience. This study aimed to investigate the effectiveness of mnemonic techniques in improving Grade VI students' retention skills in science at Caesar Z. Lanuza Elementary School. The study involved 40 Grade VI students selected through convenience sampling. A quantitative design with pre-test and post-test assessments measured retention skills before and after utilizing mnemonic devices. Results showed significant improvement, with mean scores rising from 15.25 to 22.95. The t-value of 31.64 confirmed statistical significance, highlighting mnemonics' potential in science education. Based on the conclusions drawn from the data, the study suggests that school utilizes mnemonic devices in science classrooms so that the students can learn more about it and be more excited to know more about how they can use different mnemonic devices to chunk different science content that can help them to enhance their retention skills. Future researchers may also consider the use of mnemonic devices in other subjects.