Dengue fever remains a major public health concern in the Philippines, particularly in endemic areas like Kalibo, Aklan. This study examines the factors influencing family caregivers' awareness of the potential health benefits of papaya (Carica papaya) leaves in managing dengue fever. Employing a quantitative, comparative-correlational research design, the study surveyed 349 family caregivers in a dengue hotspot barangay in Kalibo, Aklan, Philippines. Data were gathered using a validated, researcher-made questionnaire and analyzed through statistical tools, including descriptive statistics, Kruskal-Wallis test, Mann-Whitney U test, and Spearman’s rho correlation coefficient. The findings revealed that socio-demographic variables such as age, gender, education, and income significantly influenced awareness levels. Older caregivers and those with higher education demonstrated greater awareness of papaya leaves' benefits, while economic constraints often directed families toward alternative remedies. Technological factors, including access to online resources, and cultural influences within kinship and social factors also significantly shaped caregivers' understanding. Statistical analysis revealed significant differences in awareness when grouped by socio-demographic characteristics and highlighted correlations between influencing factors and awareness levels. Papaya leaves were recognized by the respondents for their therapeutic benefits, particularly in alleviating thrombocytopenia and enhancing immune response in dengue fever management. The findings emphasized the need for integrated health education programs and community-driven campaigns to promote informed and safe use of herbal treatments. By bridging traditional knowledge with evidence-based practices, the study contributes to enhancing caregiving practices and health outcomes in underserved areas in the Philippines.